WebJul 5, 2024 · Plasminogen activator inhibitor-1 (PAI-1) ... Keely S, Weaver J, Foster PS, Lawrence DA, Liu TC, Stappenbeck TS (2024) PAI-1 augments mucosal damage in … WebIn contrast, PAI-1 exacerbated mucosal damage by blocking tPA-mediated cleavage and activation of anti-inflammatory TGF-β, whereas the inhibition of PAI-1 reduced both …
Complete plasminogen activator inhibitor 1 deficiency
WebMar 28, 2024 · PAI1 was shown to promote intestinal damage and inflammation, worsening the features of DSS-induced colitis… Further investigations found that treatment with a … WebFeb 11, 2024 · Crohn’s disease is a chronic IBD that mainly occurs in the small and large intestines. Histologically, it is characterized by the fibrosis-induced thickening of the intestinal wall, mainly the submucosal layer, and an increase in smooth muscle cell growth (Van Assche et al., 2004). news google com sg
The role of plasminogen activator inhibitor (PAI)-1 in gastric mucosal ...
WebApr 9, 2024 · Pharmacological PAI-1 inhibition significantly decreased macrophage accumulation and cell senescence in atherosclerotic plaques. Recombinant PAI-1 stimulated smooth muscle cell senescence, whereas a PAI-1 mutant defective in LRP1 (LDL receptor-related protein 1) binding did not. WebPAI-1 augments mucosal damage in colitis. Kaiko G; Chen F; Lai C; et al. See more; Science Translational Medicine (2024) 11(482) DOI: 10.1126/scitranslmed.aat0852. 19 Citations. Citations of this article. 78 Readers. Mendeley users who have this article in their library. Add to library View PDF. WebDownload scientific diagram PAI-1 inhibits the tPA-dependent cleavage and activation of TGF- -suppressing epithelial hyperproliferation and colitis. (A) Immunoblot analysis of a cell-free in ... microsoft windows 10 technical support