WebNov 9, 2015 · Clock-like mutational processes in human somatic cells Ludmil B Alexandrov 1–3 , Philip H Jones 1,4 , David C W edge 1 , Julian E Sale 5 , Peter J Campbell 1,6 , Serena Nik-Zainal 1,7 & Michael ... WebFeb 5, 2024 · Alexandrov, L. B. et al. Clock-like mutational processes in human somatic cells. Nat. Genet. 47, 1402–1407 (2015). Article CAS …
Mutational signatures impact the evolution of anti-EGFR antibody ...
WebMar 19, 2024 · Previous studies have demonstrated that multiple mutational processes generate characteristic mutational signatures in human cancers. 16 Two of these processes correlate with chronologic age and have been termed clock-like mutational signatures. 17 Analysis of mutational signatures for both tumors was performed to … WebApr 30, 2024 · Based on comparative mutational signature analysis, we propose that the history of tobacco use and traumatic injury may have collaborated in activating APOBEC enzymes and the clock-like mutational process, ultimately leading to cancer formation. stamford ct car rentals
Signatures of mutational processes in human cancer - PubMed
WebNov 9, 2015 · For example, the rates of the clock-like mutational processes may vary between individuals depending on environment or lifestyle and inherited predisposition, and ancestor cells of some tumours may acquire mutator phenotypes for signatures 1 or 5 decades before the last clonal expansion. Future studies will be needed to evaluate the … WebThis process is referred to as a ‘clock-like’ mutational process because it is age-dependent and occurs at a constant rate during postnatal life [ 46 ]. Consistently, other studies have shown that the number of C > T mutations is strongly positively correlated with age [ 48 , 49 , 50 ]. WebSep 1, 2015 · Two mutational signatures show clock-like properties. Both exhibit different mutation more » rates in different tissues. However, their mutation rates are not … stamford ct community college